HitPredict

Interactor 1: ERR3 (P62508)
Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
Gene: ESRRG

Interactor 2: PNRC2 (Q9NPJ4)
Proline-rich nuclear receptor coactivator 2
Gene: PNRC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	15604093, 32296183, 14651967, unassigned1304
Identification Methods	two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 458 Hs			1 139
+	Hs
		914644 ERR3_HUMAN (1-458): 1.22e-166: 478: 100.00		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		587199 RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		370500 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		782667 HNF4A_HUMAN (82-454): 3.83e-112: 340: 26.47		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		488025 RARA_HUMAN (62-455): 5.97e-112: 339: 28.92		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		500363 RARB_HUMAN (34-455): 1.84e-121: 363: 28.37		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		510040 ERR1_HUMAN (38-456): 1.2e-109: 332: 55.32		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		530813 RARG_HUMAN (59-455): 2.33e-106: 324: 31.13		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		1055260 HNF4G_HUMAN (120-454): 5.91e-106: 322: 26.87		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		782531 HNF4A_HUMAN (82-454): 3.83e-112: 340: 26.47		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		487957 RARA_HUMAN (62-455): 5.97e-112: 339: 28.92		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		530793 RARG_HUMAN (59-455): 2.33e-106: 324: 31.13		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		1016553 HNF4G_HUMAN (120-454): 5.91e-106: 322: 26.87		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		1269696 ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		1016558 ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32