HitPredict

Interactor 1: ERR3 (P62508)
Estrogen-related receptor gamma (ERR gamma-2) (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
Gene: ESRRG

Interactor 2: PRGC1 (Q9UBK2)
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1-alpha) (PPAR-gamma coactivator 1-alpha) (PPARGC-1-alpha) (Ligand effect modulator 6)
Gene: PPARGC1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	32296183, 15821111, 19171140, unassigned1304, 18063693, 19914244
Identification Methods	two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0120162 - positive regulation of cold-induced thermogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 458 Hs			1 798
+	Mm
		250734 ERR3_MOUSE (1-458): 1.22e-166: 478: 100.00		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Mm
		250740 ERR2_MOUSE (24-458): 5.05e-143: 417: 74.94		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Hs
		587203 RXRA_HUMAN (30-456): 6.83e-128: 380: 29.85		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		500377 RARB_HUMAN (34-455): 1.84e-121: 363: 28.37		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		377770 GCR_HUMAN (2-454): 6.64e-113: 351: 26.16		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		370621 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		782680 HNF4A_HUMAN (82-454): 3.83e-112: 340: 26.47		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Mm
		250733 HNF4A_MOUSE (82-454): 1.92e-111: 338: 26.47		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Mm
		139246 ERR1_MOUSE (38-456): 3.28e-111: 336: 56.61		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Hs
		510041 ERR1_HUMAN (38-456): 1.2e-109: 332: 55.32		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Mm
		250749 NR1H3_MOUSE (41-457): 1.57e-106: 325: 23.93		PRGC1_MOUSE (1-798): 0: 1210: 94.49
+	Hs
		795608 NR4A2_HUMAN (34-454): 5.59e-100: 313: 28.31		PRGC1_HUMAN (1-798): 0: 1210: 100.00
+	Hs
		914660 ERR3_HUMAN (1-458): 1.22e-166: 478: 100.00		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		369945 ESR1_HUMAN (32-457): 2.07e-114: 350: 32.61		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		782588 HNF4A_HUMAN (82-454): 3.83e-112: 340: 26.47		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		510026 ERR1_HUMAN (38-456): 1.2e-109: 332: 55.32		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Hs
		874389 NR1H2_HUMAN (43-457): 6.73e-107: 326: 23.23		PRGC2_HUMAN (24-220): 2.66e-61: 226: 36.45
+	Mm
		139251 ERR1_MOUSE (38-456): 3.28e-111: 336: 56.61		PRGC2_MOUSE (237-467): 1.97e-54: 205: 29.74
+	Mm
		1257603 NR1H3_MOUSE (41-457): 1.57e-106: 325: 23.93		PRGC2_MOUSE (237-467): 1.97e-54: 205: 29.74
+	Hs
		1138792 ESR2_HUMAN (127-458): 1.2e-72: 239: 39.50		PPRC1_HUMAN (663-798): 1.32e-57: 216: 61.03