HitPredict

Interactor 1: PP2AB (P62715)
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)
Gene: Ppp2cb

Interactor 2: 2AAA (Q76MZ3)
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
Gene: Ppp2r1a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24390425
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HEAT~Metallophos, HEAT_2~Metallophos
Common GO terms	GO:0000159 - protein phosphatase type 2A complex GO:0000775 - chromosome, centromeric region GO:0004722 - protein serine/threonine phosphatase activity GO:0005634 - nucleus GO:0005737 - cytoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 309 Mm			1 589
+	Hs
		672079 PP2AA_HUMAN (1-309): 0: 533: 97.41		2AAA_HUMAN (1-589): 5.57e-167: 489: 99.83
+	Mm
		930638 PP2AA_MOUSE (1-309): 0: 532: 97.41		2AAA_MOUSE (1-589): 4.58e-167: 490: 100.00
+	Hs
		672072 PP2AB_HUMAN (1-309): 0: 532: 100.00		2AAA_HUMAN (1-589): 5.57e-167: 489: 99.83
+	Hs
		87320 PP2AA_HUMAN (1-309): 0: 533: 97.41		C9J9C1_HUMAN (1-589): 2.51e-162: 479: 93.32
+	Hs
		87319 PP2AB_HUMAN (1-309): 0: 532: 100.00		C9J9C1_HUMAN (1-589): 2.51e-162: 479: 93.32
+	Hs
		672402 PP2AA_HUMAN (1-309): 0: 533: 97.41		2AAB_HUMAN (9-589): 1.32e-158: 468: 86.40
+	Hs
		672060 PP4C_HUMAN (4-309): 0: 511: 64.50		2AAA_HUMAN (1-589): 5.57e-167: 489: 99.83
+	Hs
		672399 PP2AB_HUMAN (1-309): 0: 532: 100.00		2AAB_HUMAN (9-589): 1.32e-158: 468: 86.40
+	Hs
		672395 PP4C_HUMAN (4-309): 0: 511: 64.50		2AAB_HUMAN (9-589): 1.32e-158: 468: 86.40
+	Dm
		619857 PP2A_DROME (1-309): 0: 527: 94.50		2AAA_DROME (1-578): 1e-146: 438: 75.17
+	Mm
		956531 PP4C_MOUSE (4-309): 0: 511: 64.50		PP4R4_MOUSE (25-487): 1.02e-37: 151: 17.39
+	Hs
		268640 PP4C_HUMAN (4-309): 0: 511: 64.50		SF3B1_HUMAN (12-589): 1.41e-28: 123: 12.89
+	Hs
		268648 PP1A_HUMAN (5-296): 0: 508: 47.18		SF3B1_HUMAN (12-589): 1.41e-28: 123: 12.89
+	Sc
		618820 PP2A2_YEAST (9-309): 0: 531: 76.08		2AAA_YEAST (13-235): 8.67e-13: 73.3: 23.18
+	Hs
		930933 PP2AA_HUMAN (1-309): 0: 533: 97.41		PP4R1_HUMAN (325-583): 8.14e-09: 60.9: 17.78
+	Hs
		915244 PP2AB_HUMAN (1-309): 0: 532: 100.00		PP4R1_HUMAN (325-583): 8.14e-09: 60.9: 17.78
+	Sc
		618757 PP2A1_YEAST (7-309): 0: 519: 74.92		2AAA_YEAST (13-235): 8.67e-13: 73.3: 23.18
+	Hs
		890979 PP4C_HUMAN (4-309): 0: 511: 64.50		PP4R4_HUMAN (13-411): 1.26e-12: 72.9: 16.71
+	Bt
		61642 PP4C_BOVIN (4-309): 0: 511: 64.50		F1MRS1_BOVIN (325-583): 5.72e-09: 61.2: 17.04
+	Hs
		890987 PP4C_HUMAN (4-309): 0: 511: 64.50		PP4R1_HUMAN (325-583): 8.14e-09: 60.9: 17.78