HitPredict

Interactor 1: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Interactor 2: NEXN (Q0ZGT2)
Nexilin (F-actin-binding protein) (Nelin)
Gene: NEXN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~I-set
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 675
+	Hs
		1013392 ACTBL_HUMAN (4-377): 0: 712: 87.97		NEXN_HUMAN (1-675): 7.23e-105: 335: 100.00
+	Hs
		891727 ACTB_HUMAN (4-377): 0: 598: 94.12		NEXN_HUMAN (1-675): 7.23e-105: 335: 100.00
+	Hs
		932119 ACTC_HUMAN (1-377): 0: 598: 98.41		NEXN_HUMAN (1-675): 7.23e-105: 335: 100.00
+	Hs
		507933 ACTB_HUMAN (4-377): 0: 598: 94.12		FGFR1_HUMAN (349-674): 4.83e-41: 162: 13.51
+	Hs
		507942 ACTG_HUMAN (4-377): 0: 598: 94.39		FGFR1_HUMAN (349-674): 4.83e-41: 162: 13.51
+	Hs
		507943 ACTS_HUMAN (1-377): 0: 598: 97.88		FGFR1_HUMAN (349-674): 4.83e-41: 162: 13.51
+	Hs
		891771 ACTB_HUMAN (4-377): 0: 598: 94.12		MYPC3_HUMAN (10-653): 5.58e-32: 135: 11.78
+	Hs
		932159 ACTC_HUMAN (1-377): 0: 598: 98.41		MYPC3_HUMAN (10-653): 5.58e-32: 135: 11.78
+	Mm
		250929 ACTC_MOUSE (1-377): 0: 598: 98.41		MYPC3_MOUSE (238-674): 4.61e-12: 71.8: 11.09
+	Hs
		891928 ACTB_HUMAN (4-377): 0: 598: 94.12		PALLD_HUMAN (573-675): 5.3e-11: 68.3: 23.08
+	Dm
		54871 ACT6_DROME (1-377): 0: 593: 92.84		A1ZA72_DROME (357-675): 3.84e-10: 65.7: 13.08