HitPredict

Interactor 1: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 33961781, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Actin
Common GO terms	GO:0005524 - ATP binding GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0019901 - protein kinase binding GO:0070062 - extracellular exosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 376
+	Hs
		891818 ACTBL_HUMAN (4-377): 0: 712: 87.97		ACTB_HUMAN (3-376): 0: 596: 91.71
+	Hs
		932195 ACTBL_HUMAN (4-377): 0: 712: 87.97		ACTC_HUMAN (2-376): 0: 590: 88.27
+	Dm
		361164 ACT4_DROME (1-377): 0: 647: 92.04		ACT5_DROME (1-376): 0: 598: 89.10
+	Dm
		361129 ACT4_DROME (1-377): 0: 647: 92.04		ACT2_DROME (1-376): 0: 596: 90.16
+	Dm
		361177 ACT4_DROME (1-377): 0: 647: 92.04		ACT3_DROME (1-376): 0: 596: 88.83
+	Dm
		361179 ACT4_DROME (1-377): 0: 647: 92.04		ACT6_DROME (1-376): 0: 596: 88.83
+	Sp
		501575 ACT_SCHPO (4-377): 0: 644: 89.04		ACT_SCHPO (3-376): 0: 587: 85.29
+	Sc
		887643 ACT_YEAST (4-377): 0: 643: 86.63		ACT_YEAST (1-376): 0: 585: 82.98
+	Ce
		501463 ACT2_CAEEL (1-377): 0: 599: 94.43		ACT2_CAEEL (1-376): 0: 601: 90.16
+	Ce
		501464 ACT2_CAEEL (1-377): 0: 599: 94.43		ACT4_CAEEL (1-376): 0: 601: 90.16
+	Ce
		483542 ACT2_CAEEL (1-377): 0: 599: 94.43		ACT3_CAEEL (1-376): 0: 599: 90.16
+	Ce
		483543 ACT4_CAEEL (1-377): 0: 599: 93.90		ACT3_CAEEL (1-376): 0: 599: 90.16
+	Ce
		483541 ACT3_CAEEL (1-377): 0: 598: 93.63		ACT3_CAEEL (1-376): 0: 599: 90.16
+	Gg
		891646 ACTB_CHICK (4-377): 0: 598: 94.12		ACTB_CHICK (3-376): 0: 596: 91.71
+	Hs
		929883 Q1KLZ0_HUMAN (4-377): 0: 598: 94.12		ACTG_HUMAN (3-376): 0: 595: 91.44
+	Oc
		933098 ACTS_RABIT (1-377): 0: 598: 97.88		ACTS_RABIT (2-376): 0: 590: 87.47
+	Gg
		933103 ACTS_CHICK (1-377): 0: 598: 97.88		ACTS_CHICK (2-376): 0: 590: 87.47