HitPredict

Interactor 1: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Interactor 2: FMNL3 (Q8IVF7)
Formin-like protein 3 (Formin homology 2 domain-containing protein 3) (WW domain-binding protein 3) (WBP-3)
Gene: FMNL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~FH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 1028
+	Hs
		1122441 ACTBL_HUMAN (4-377): 0: 712: 87.97		FMNL3_HUMAN (1-1028): 0: 1050: 100.00
+	Hs
		929974 ACTG_HUMAN (4-377): 0: 598: 94.39		FMNL2_HUMAN (1-1025): 0: 986: 66.94
+	Hs
		892135 ACTB_HUMAN (4-377): 0: 598: 94.12		DAAM1_HUMAN (19-1015): 0: 713: 21.56
+	Hs
		892064 ACTB_HUMAN (4-377): 0: 598: 94.12		DIAP3_HUMAN (92-1012): 0: 635: 20.42
+	Hs
		892076 ACTB_HUMAN (4-377): 0: 598: 94.12		FMN2_HUMAN (516-965): 2.32e-106: 367: 18.09
+	Hs
		930029 ACTG_HUMAN (4-377): 0: 598: 94.39		FMN2_HUMAN (516-965): 2.32e-106: 367: 18.09
+	Hs
		932414 ACTC_HUMAN (1-377): 0: 598: 98.41		FMN2_HUMAN (516-965): 2.32e-106: 367: 18.09
+	Hs
		891803 ACTB_HUMAN (4-377): 0: 598: 94.12		INF2_HUMAN (537-1021): 7.68e-103: 352: 21.98
+	Hs
		929884 ACTG_HUMAN (4-377): 0: 598: 94.39		INF2_HUMAN (537-1021): 7.68e-103: 352: 21.98
+	Hs
		932188 ACTC_HUMAN (1-377): 0: 598: 98.41		INF2_HUMAN (537-1021): 7.68e-103: 352: 21.98
+	Sc
		773864 ACT_YEAST (4-377): 0: 643: 86.63		BNR1_YEAST (537-979): 1.22e-85: 304: 23.08
+	Hs
		892145 ACTB_HUMAN (4-377): 0: 598: 94.12		FHOD1_HUMAN (557-1021): 2.01e-99: 341: 18.52
+	Hs
		930071 ACTG_HUMAN (4-377): 0: 598: 94.39		FHOD1_HUMAN (557-1021): 2.01e-99: 341: 18.52
+	Dm
		361147 ACT2_DROME (1-377): 0: 595: 93.63		Q8SY43_DROME (565-970): 3.49e-89: 314: 18.77
+	Hs
		237575 ACTB_HUMAN (4-377): 0: 598: 94.12		DIAP1_HUMAN (104-507): 1.29e-82: 294: 18.09
+	Hs
		237587 ACTC_HUMAN (1-377): 0: 598: 98.41		DIAP1_HUMAN (104-507): 1.29e-82: 294: 18.09
+	Sc
		784637 ACT_YEAST (4-377): 0: 643: 86.63		BNI1_YEAST (570-962): 1.41e-16: 87.4: 24.07