HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: SHPS1 (P78324)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
Gene: SIRPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0070062 - extracellular exosome GO:0070301 - cellular response to hydrogen peroxide
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 504
+	Hs
		915663 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		CD166_HUMAN (1-312): 3.34e-54: 193: 18.62
+	Hs
		892359 RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54		CD166_HUMAN (1-312): 3.34e-54: 193: 18.62
+	Hs
		925776 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		901110 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		916112 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		436602 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		894644 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		915989 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ROBO2_HUMAN (24-494): 2.34e-25: 112: 11.56
+	Hs
		894276 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		PXDN_HUMAN (228-487): 3.51e-25: 112: 14.23
+	Hs
		925521 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		900803 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		915896 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		545561 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		436458 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		951238 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		894314 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Ce
		136793 RAC1_CAEEL (1-196): 5.29e-80: 238: 53.57		UNC89_CAEEL (158-493): 2.63e-16: 84.8: 11.99
+	Ce
		104464 G5EBV3_CAEEL (2-196): 7.03e-76: 227: 48.72		UNC89_CAEEL (158-493): 2.63e-16: 84.8: 11.99
+	Ce
		136800 RHO1_CAEEL (1-196): 4.36e-75: 225: 78.57		UNC89_CAEEL (158-493): 2.63e-16: 84.8: 11.99
+	Hs
		894044 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		MYLK_HUMAN (231-481): 5.31e-12: 70.9: 9.66