HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005769 - early endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion and 1 others more... GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 393
+	Hs
		925211 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00
+	Hs
		647868 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		900394 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00
+	Hs
		734906 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		647858 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		647867 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		545213 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		625333 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		681775 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		AKT1_HUMAN (39-389): 1.97e-120: 359: 19.44
+	Hs
		734901 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		436165 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		647872 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		647855 RAC3_HUMAN (1-179): 1.15e-74: 224: 57.54		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		647856 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Hs
		734900 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		MP2K2_HUMAN (1-391): 2.96e-123: 363: 79.40
+	Hs
		436162 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27
+	Hs
		564418 RHOQ_HUMAN (2-195): 6.71e-68: 207: 51.74		MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72
+	Ce
		104466 G5EBV3_CAEEL (2-196): 7.03e-76: 227: 48.72		Q304D8_CAEEL (38-366): 4.1e-104: 315: 30.42
+	Ce
		104472 G5EBV3_CAEEL (2-196): 7.03e-76: 227: 48.72		CST1_CAEEL (38-366): 1.04e-102: 314: 30.42
+	Hs
		805371 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		MP2K3_HUMAN (53-380): 1.39e-65: 214: 36.69