HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ras, Ank_2~Ras
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0043065 - positive regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 2471
+	Hs
		925219 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		900403 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		545337 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		950942 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		804195 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		804189 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		804194 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		545253 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		804203 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		925238 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		900423 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		915638 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		950953 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		925204 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01
+	Hs
		724336 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		FBN1_HUMAN (201-1638): 9.66e-69: 261: 18.41
+	Hs
		916082 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		JAG2_HUMAN (2-501): 6.2e-66: 249: 33.21
+	Hs
		925184 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		JAG1_HUMAN (1136-1552): 1.01e-29: 131: 20.42
+	Hs
		915599 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		JAG1_HUMAN (1136-1552): 1.01e-29: 131: 20.42
+	Hs
		545315 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		JAG1_HUMAN (1136-1552): 1.01e-29: 131: 20.42
+	Hs
		944117 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		JAG1_HUMAN (1136-1552): 1.01e-29: 131: 20.42