HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1748
+	Hs
		900411 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		159189 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Hs
		159188 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		CSKP_HUMAN (217-806): 6.5e-86: 305: 14.66
+	Hs
		925341 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MPP7_HUMAN (310-807): 3.29e-83: 287: 14.96
+	Hs
		915829 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		PALS1_HUMAN (272-806): 1.75e-82: 288: 15.67
+	Hs
		915736 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		MPP7_HUMAN (310-807): 3.29e-83: 287: 14.96
+	Hs
		915880 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		DLG3_HUMAN (21-427): 4.69e-51: 197: 17.51
+	Mm
		925797 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		DLG4_MOUSE (1-112): 2.37e-27: 122: 29.92
+	Hs
		925236 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		900421 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		915636 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		PTN13_HUMAN (20-492): 4.02e-23: 110: 16.63
+	Hs
		915848 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77
+	Hs
		925457 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Hs
		925239 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		915856 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		DLG5_HUMAN (262-508): 3.83e-17: 90.3: 21.43
+	Hs
		915639 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		306910 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		UNC5C_HUMAN (1635-1728): 1.98e-13: 77.8: 47.37
+	Hs
		925426 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		UNC5B_HUMAN (1634-1718): 3.49e-11: 70.5: 44.71
+	Hs
		915821 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		UNC5B_HUMAN (1634-1718): 3.49e-11: 70.5: 44.71
+	Hs
		916046 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98