HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: PAK2 (Q13177)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Gene: PAK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0007165 - signal transduction and 1 others more... GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 524
+	Hs
		925245 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Hs
		900433 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		PAK2_HUMAN (1-524): 0: 538: 100.00
+	Mm
		925809 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		PAK2_MOUSE (1-524): 0: 531: 97.14
+	Mm
		103566 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		G5E884_MOUSE (1-523): 2.64e-169: 491: 74.95
+	Hs
		925244 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63
+	Mm
		292040 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		PAK1_MOUSE (1-523): 1.84e-167: 486: 73.35
+	Mm
		292048 RHOA_MOUSE (1-196): 3.27e-78: 233: 83.16		PAK1_MOUSE (1-523): 1.84e-167: 486: 73.35
+	Hs
		277602 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PAK3_HUMAN (1-523): 8.9e-162: 472: 71.71
+	Ce
		975572 RAC1_CAEEL (1-196): 5.29e-80: 238: 53.57		PK1_CAEEL (9-522): 1.29e-137: 411: 52.21
+	Hs
		681775 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		AKT1_HUMAN (141-523): 1.99e-133: 397: 21.83
+	Dd
		710116 RAC1A_DICDI (1-196): 1.18e-80: 239: 52.04		PAKB_DICDI (39-523): 2.76e-123: 383: 35.71
+	Hs
		568619 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91
+	Dd
		710117 RAC1B_DICDI (1-196): 3.13e-80: 238: 51.02		PAKB_DICDI (39-523): 2.76e-123: 383: 35.71
+	Hs
		568611 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91
+	Dm
		776912 RAC1_DROME (1-196): 1.58e-77: 231: 53.06		Q9VEV1_DROME (186-523): 3.1e-127: 384: 53.24
+	Dm
		1177643 Q7JWS8_DROME (1-196): 8.76e-78: 232: 51.78		PAK_DROME (8-177): 3.93e-22: 102: 36.96
+	Hs
		925692 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PAK5_HUMAN (67-179): 3.87e-12: 70.7: 25.64
+	Hs
		925648 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PAK6_HUMAN (65-127): 1.59e-10: 65.7: 38.10
+	Hs
		330967 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55
+	Hs
		330955 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55