HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: HERC1 (Q15751)
Probable E3 ubiquitin-protein ligase HERC1 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 1) (HECT-type E3 ubiquitin transferase HERC1) (p532) (p619)
Gene: HERC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RCC1~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 4861
+	Rn
		88544 RHOA_RAT (1-196): 3.27e-78: 233: 83.16		D3ZCF5_RAT (4320-4843): 4.58e-167: 537: 22.91
+	Mm
		56825 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		SMUF2_MOUSE (4334-4843): 5.98e-165: 532: 23.79
+	Hs
		900923 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		SMUF2_HUMAN (4334-4843): 2.33e-164: 530: 23.60
+	Hs
		900929 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		SMUF1_HUMAN (4320-4843): 8.67e-163: 526: 22.58
+	Hs
		915987 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SMUF1_HUMAN (4320-4843): 8.67e-163: 526: 22.58
+	Hs
		808080 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		NEDD4_HUMAN (4360-4841): 3.39e-153: 517: 20.97
+	Hs
		925520 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ITCH_HUMAN (4369-4843): 2.48e-157: 516: 23.03
+	Hs
		900802 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ITCH_HUMAN (4369-4843): 2.48e-157: 516: 23.03
+	Hs
		915895 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ITCH_HUMAN (4369-4843): 2.48e-157: 516: 23.03
+	Hs
		915900 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		NED4L_HUMAN (4355-4841): 1.54e-156: 516: 19.68
+	Hs
		125349 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		WWP2_HUMAN (4369-4843): 4.38e-156: 511: 21.36
+	Hs
		545560 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		ITCH_HUMAN (4369-4843): 2.48e-157: 516: 23.03
+	Hs
		125308 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		WWP2_HUMAN (4369-4843): 4.38e-156: 511: 21.36
+	Hs
		125330 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		WWP2_HUMAN (4369-4843): 4.38e-156: 511: 21.36
+	Hs
		951237 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		ITCH_HUMAN (4369-4843): 2.48e-157: 516: 23.03
+	Hs
		125135 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		WWP2_HUMAN (4369-4843): 4.38e-156: 511: 21.36
+	Hs
		125372 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		WWP2_HUMAN (4369-4843): 4.38e-156: 511: 21.36
+	Hs
		925397 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		HUWE1_HUMAN (4372-4842): 8.91e-133: 474: 21.86
+	Hs
		925423 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		HACE1_HUMAN (4316-4837): 1.6e-136: 455: 21.47
+	Hs
		900763 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		RPGR_HUMAN (368-583): 3.19e-14: 82: 28.25