HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: RGPA2 (Q2PPJ7)
Ral GTPase-activating protein subunit alpha-2 (250 kDa substrate of Akt) (AS250) (p220)
Gene: RALGAPA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rap_GAP~Ras
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1873
+	Hs
		951036 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		RGPA2_HUMAN (1-1873): 0: 2869: 100.00
+	Hs
		925359 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		900583 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		915756 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		951081 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		894131 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		RGPA1_HUMAN (1-851): 0: 1225: 48.66
+	Hs
		925407 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		900651 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		915799 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		951126 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		894180 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		RLGPB_HUMAN (993-1802): 3.58e-139: 473: 17.54
+	Hs
		835036 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		TSC2_HUMAN (1477-1868): 4.37e-100: 360: 23.42
+	Hs
		196428 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SI1L1_HUMAN (1544-1861): 3.5e-92: 335: 19.45
+	Hs
		916041 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SI1L2_HUMAN (1544-1861): 8.65e-90: 327: 20.67
+	Hs
		925514 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		SIPA1_HUMAN (1545-1859): 7.89e-90: 319: 21.23
+	Hs
		900790 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		SIPA1_HUMAN (1545-1859): 7.89e-90: 319: 21.23
+	Hs
		230233 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		SI1L3_HUMAN (1534-1859): 2.76e-83: 306: 20.35
+	Hs
		230232 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SI1L3_HUMAN (1534-1859): 2.76e-83: 306: 20.35
+	Dm
		776929 RAC1_DROME (1-196): 1.58e-77: 231: 53.06		X2JDH0_DROME (1505-1859): 1.71e-80: 297: 18.06
+	Dm
		776932 RAC1_DROME (1-196): 1.58e-77: 231: 53.06		X2JJU0_DROME (1505-1859): 1.6e-80: 297: 18.06