HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: MRCKA (Q5VT25)
Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42-binding protein kinase alpha) (DMPK-like alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (MRCK alpha) (Myotonic dystrophy protein kinase-like alpha)
Gene: CDC42BPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1732
+	Hs
		925344 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MRCKA_HUMAN (1-1732): 0: 1615: 100.00
+	Hs
		925766 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		916101 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		MRCKB_HUMAN (1-1731): 0: 1417: 60.38
+	Hs
		925356 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MRCKG_HUMAN (4-1712): 0: 1145: 39.90
+	Hs
		925229 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		DMPK_HUMAN (1-539): 8.55e-141: 451: 48.17
+	Hs
		148653 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Hs
		148608 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Hs
		148632 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		CTRO_HUMAN (4-1044): 3.09e-128: 447: 24.43
+	Rn
		92842 RHOA_RAT (1-196): 3.27e-78: 233: 83.16		CTRO_RAT (4-1025): 1.66e-127: 445: 23.89
+	Mm
		823530 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		CTRO_MOUSE (4-1025): 1.07e-120: 424: 23.41
+	Mm
		823539 RHOA_MOUSE (1-196): 3.27e-78: 233: 83.16		CTRO_MOUSE (4-1025): 1.07e-120: 424: 23.41
+	Hs
		681775 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		AKT1_HUMAN (13-404): 1.23e-128: 413: 31.51
+	Hs
		916061 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		TNIK_HUMAN (53-905): 4.35e-97: 346: 15.60
+	Mm
		925783 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		TNIK_MOUSE (53-700): 2.14e-94: 337: 15.88
+	Hs
		254468 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		254464 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		254467 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ROCK2_HUMAN (373-1052): 1.4e-22: 108: 12.07
+	Hs
		925253 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		900444 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28
+	Hs
		915655 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ROCK1_HUMAN (361-1052): 1.07e-20: 101: 11.28