HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: RGPA1 (Q6GYQ0)
Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240)
Gene: RALGAPA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Rap_GAP~Ras
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 2036
+	Hs
		925359 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		RGPA1_HUMAN (1-2036): 0: 2954: 100.00
+	Hs
		900583 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		RGPA1_HUMAN (1-2036): 0: 2954: 100.00
+	Hs
		951081 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		RGPA1_HUMAN (1-2036): 0: 2954: 100.00
+	Hs
		894131 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		RGPA1_HUMAN (1-2036): 0: 2954: 100.00
+	Hs
		915714 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		RGPA2_HUMAN (1-2030): 0: 2671: 49.46
+	Hs
		951036 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		RGPA2_HUMAN (1-2030): 0: 2671: 49.46
+	Hs
		925514 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		SIPA1_HUMAN (1603-2018): 1.13e-117: 402: 16.91
+	Hs
		900790 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		SIPA1_HUMAN (1603-2018): 1.13e-117: 402: 16.91
+	Hs
		196428 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SI1L1_HUMAN (1683-2015): 2.28e-106: 380: 19.22
+	Hs
		916041 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SI1L2_HUMAN (1694-2016): 4.06e-106: 379: 18.88
+	Hs
		925407 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		900651 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		915799 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		951126 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		894180 CDC42_HUMAN (1-196): 1.35e-74: 224: 49.49		RLGPB_HUMAN (1126-1884): 1.5e-105: 375: 16.67
+	Hs
		230233 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		SI1L3_HUMAN (1691-2016): 1.32e-100: 362: 18.83
+	Dm
		776929 RAC1_DROME (1-196): 1.58e-77: 231: 53.06		X2JDH0_DROME (1637-2013): 4.12e-102: 367: 21.16
+	Dm
		776932 RAC1_DROME (1-196): 1.58e-77: 231: 53.06		X2JJU0_DROME (1637-2013): 3.69e-102: 367: 21.16
+	Hs
		230232 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		SI1L3_HUMAN (1691-2016): 1.32e-100: 362: 18.83
+	Hs
		835036 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		TSC2_HUMAN (1727-2033): 1.18e-96: 349: 23.90