HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: RHPN2 (Q8IUC4)
Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)
Gene: RHPN2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.800

Property	Details
Experiments	12473120, 31871319
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HR1~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 686
+	Hs
		900659 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		RHPN2_HUMAN (1-686): 0: 841: 100.00
+	Hs
		900719 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		RHPN1_HUMAN (23-675): 0: 618: 41.60
+	Hs
		915745 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		BROX_HUMAN (116-523): 2.18e-77: 255: 16.86
+	Hs
		951362 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		GOPC_HUMAN (196-600): 7.01e-56: 199: 14.29
+	Hs
		158270 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		LIN7A_HUMAN (421-601): 2.76e-30: 121: 14.52
+	Hs
		167081 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHGB_HUMAN (472-600): 1.16e-24: 112: 21.71
+	Hs
		167078 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ARHGB_HUMAN (472-600): 1.16e-24: 112: 21.71
+	Hs
		167079 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ARHGB_HUMAN (472-600): 1.16e-24: 112: 21.71
+	Hs
		167063 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		ARHGB_HUMAN (472-600): 1.16e-24: 112: 21.71
+	Mm
		925797 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		DLG4_MOUSE (467-663): 9.11e-15: 79.9: 14.83
+	Hs
		900985 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ARHGC_HUMAN (513-600): 1.6e-15: 82.9: 22.73
+	Hs
		916029 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ARHGC_HUMAN (513-600): 1.6e-15: 82.9: 22.73
+	Hs
		925239 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		900424 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		915639 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		545346 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		950954 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		DLG1_HUMAN (434-636): 2.48e-13: 75.6: 14.87
+	Hs
		900762 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		DLG3_HUMAN (515-636): 2.59e-10: 65.6: 14.18
+	Hs
		915880 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		DLG3_HUMAN (515-636): 2.59e-10: 65.6: 14.18
+	Hs
		951207 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		DLG3_HUMAN (515-636): 2.59e-10: 65.6: 14.18