HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: NGEF (Q8N5V2)
Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
Gene: NGEF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	19637314
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 710
+	Hs
		925436 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		NGEF_HUMAN (1-710): 0: 540: 100.00
+	Hs
		925512 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHGQ_HUMAN (20-691): 1.64e-119: 380: 27.26
+	Hs
		925416 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHGJ_HUMAN (10-691): 1.19e-115: 368: 30.24
+	Hs
		925527 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		SPT13_HUMAN (37-630): 3.84e-102: 328: 14.08
+	Hs
		925649 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHG4_HUMAN (9-644): 1.24e-101: 328: 15.36
+	Hs
		548678 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		VAV_HUMAN (152-709): 1.25e-98: 324: 15.87
+	Hs
		167081 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHGB_HUMAN (3-708): 5.04e-93: 318: 15.16
+	Hs
		167079 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ARHGB_HUMAN (3-708): 5.04e-93: 318: 15.16
+	Hs
		925718 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		VAV3_HUMAN (167-708): 6.57e-93: 309: 12.16
+	Mm
		650205 RHOA_MOUSE (1-196): 3.27e-78: 233: 83.16		RGRF1_MOUSE (76-638): 4.34e-90: 308: 15.78
+	Hs
		925382 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PREX2_HUMAN (251-614): 2.77e-86: 299: 19.48
+	Hs
		925624 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ECT2_HUMAN (146-681): 1.79e-88: 298: 15.87
+	Hs
		855782 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		VAV2_HUMAN (167-682): 4.63e-88: 296: 13.88
+	Hs
		925271 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		ARHG7_HUMAN (26-628): 1.28e-87: 294: 12.22
+	Hs
		925455 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		PREX1_HUMAN (223-613): 3.34e-83: 290: 19.66
+	Hs
		156397 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		RGRF2_HUMAN (76-598): 4.72e-83: 288: 15.48
+	Hs
		279854 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		TRIO_HUMAN (262-658): 2.58e-58: 216: 19.19
+	Hs
		224711 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		KALRN_HUMAN (262-672): 7.64e-57: 212: 18.87
+	Hs
		279853 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		TRIO_HUMAN (262-658): 2.58e-58: 216: 19.19
+	Sp
		1000083 RHO1_SCHPO (1-194): 2.96e-81: 241: 68.21		RGF3_SCHPO (271-530): 5.67e-11: 68.2: 25.46