HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 31871319
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030336 - negative regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 1919
+	Hs
		925457 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Hs
		900722 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Hs
		900762 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		DLG3_HUMAN (1133-1916): 5.4e-177: 560: 18.97
+	Hs
		915880 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		DLG3_HUMAN (1133-1916): 5.4e-177: 560: 18.97
+	Hs
		925239 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Mm
		925797 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Hs
		900424 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		915639 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		545346 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		950954 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		DLG1_HUMAN (1057-1916): 2.05e-154: 501: 19.62
+	Hs
		925341 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		MPP7_HUMAN (1465-1915): 4.41e-107: 356: 20.37
+	Hs
		900562 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		MPP7_HUMAN (1465-1915): 4.41e-107: 356: 20.37
+	Hs
		915736 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		MPP7_HUMAN (1465-1915): 4.41e-107: 356: 20.37
+	Hs
		545425 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		MPP7_HUMAN (1465-1915): 4.41e-107: 356: 20.37
+	Hs
		900683 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		PALS1_HUMAN (1501-1916): 9.35e-98: 333: 19.50
+	Hs
		915829 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		PALS1_HUMAN (1501-1916): 9.35e-98: 333: 19.50
+	Hs
		901012 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		916046 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		900411 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81
+	Hs
		915627 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81