HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: ARHG1 (Q92888)
Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)
Gene: ARHGEF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.883

The method score is based on:

Property Details
Experiments 34079125, 33961781, 31871319, 19637314
Identification Methods proximity labelling technology, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH_16~Ras, Ras~RhoGEF
Common GO terms GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007266 - Rho protein signal transduction
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 196
Hs

1 912
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024