HitPredict

Interactor 1: RHOB (P62745)
Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)
Gene: RHOB

Interactor 2: GDIR3 (Q99819)
Rho GDP-dissociation inhibitor 3 (Rho GDI 3) (Rho-GDI gamma)
Gene: ARHGDIG

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	8939998
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007266 - Rho protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 196 Hs			1 225
+	Hs
		925561 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		GDIR3_HUMAN (1-225): 1.49e-115: 330: 100.00
+	Hs
		900840 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		GDIR3_HUMAN (1-225): 1.49e-115: 330: 100.00
+	Hs
		951270 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		GDIR3_HUMAN (1-225): 1.49e-115: 330: 100.00
+	Mm
		925816 RAC1_MOUSE (1-196): 2.37e-79: 236: 55.10		GDIR1_MOUSE (36-225): 6.84e-105: 302: 60.53
+	Hs
		854769 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Rn
		901290 RHOA_RAT (1-196): 3.27e-78: 233: 83.16		GDIR1_RAT (36-225): 6.84e-105: 302: 60.53
+	Hs
		854763 RHOA_HUMAN (1-196): 7.19e-78: 232: 83.67		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		854767 RHOB_HUMAN (1-196): 7.52e-78: 232: 100.00		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		545278 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		436218 RHOC_HUMAN (1-196): 8.84e-76: 227: 83.16		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		854771 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		GDIR1_HUMAN (36-225): 1.46e-104: 301: 61.05
+	Hs
		854851 RAC1_HUMAN (1-196): 2.37e-79: 236: 55.10		GDIR2_HUMAN (47-225): 5.49e-96: 280: 60.89
+	Hs
		545279 RAC2_HUMAN (1-196): 7.63e-77: 230: 53.57		GDIR2_HUMAN (47-225): 5.49e-96: 280: 60.89
+	Hs
		854852 RHOG_HUMAN (1-196): 8.84e-76: 227: 51.53		GDIR2_HUMAN (47-225): 5.49e-96: 280: 60.89
+	At
		1105129 RAC3_ARATH (2-196): 6.49e-83: 245: 47.48		GDIR_ARATH (27-223): 4.23e-80: 241: 28.64
+	Dm
		816393 RHO1_DROME (1-196): 5.31e-75: 225: 80.10		Q9VW59_DROME (28-223): 7.56e-84: 249: 42.21
+	Sc
		419734 RHO1_YEAST (3-186): 1.7e-88: 260: 67.39		GDIR_YEAST (47-222): 8.14e-70: 213: 36.41
+	Ce
		975573 RAC1_CAEEL (1-196): 5.29e-80: 238: 53.57		GDIR_CAEEL (47-222): 9.12e-76: 228: 37.29
+	Ce
		1093791 RHO1_CAEEL (1-196): 4.36e-75: 225: 78.57		GDIR_CAEEL (47-222): 9.12e-76: 228: 37.29
+	Cl
		47354 RAC1_CANLF (1-196): 2.37e-79: 236: 55.10		A0A8I3N6C6_CANLF (36-225): 9.11e-70: 212: 44.21