HitPredict

Interactor 1: RS6 (P62753)
Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33)
Gene: RPS6

Interactor 2: KS6A1 (Q15418)
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
Gene: RPS6KA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21423205
Identification Methods	protein kinase assay
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 249 Hs			1 735
+	Dm
		665702 RS6_DROME (1-238): 3.3e-103: 301: 76.57		Q24496_DROME (2-729): 0: 713: 50.64
+	Dm
		665724 RS6_DROME (1-238): 3.3e-103: 301: 76.57		Q9VR61_DROME (2-729): 0: 713: 50.64
+	Hs
		916943 RS6_HUMAN (1-249): 9.61e-112: 322: 100.00		KS6B2_HUMAN (418-727): 1.07e-114: 356: 27.74
+	Hs
		616692 RS6_HUMAN (1-249): 9.61e-112: 322: 100.00		KS6B1_HUMAN (393-727): 4.37e-113: 353: 24.65
+	Mm
		917013 RS6_MOUSE (1-249): 9.61e-112: 322: 100.00		KS6B1_MOUSE (393-727): 4.47e-113: 353: 24.65
+	Hs
		568618 RS6_HUMAN (1-249): 9.61e-112: 322: 100.00		KAPCA_HUMAN (414-712): 3.66e-114: 350: 29.71
+	Hs
		610706 RS6_HUMAN (1-249): 9.61e-112: 322: 100.00		KAPCB_HUMAN (406-704): 9.71e-114: 349: 30.03
+	Hs
		916599 RS6_HUMAN (1-249): 9.61e-112: 322: 100.00		KS6A2_HUMAN (2-321): 2.57e-98: 321: 23.80
+	Sp
		1319473 RS6B_SCHPO (1-238): 1.83e-105: 306: 68.75		GAD8_SCHPO (416-679): 2.66e-27: 119: 30.04
+	Sp
		1015735 RS6B_SCHPO (1-238): 1.83e-105: 306: 68.75		PSK1_SCHPO (424-666): 1.27e-22: 103: 30.28