HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: ORC1 (Q13415)
Origin recognition complex subunit 1 (Replication control protein 1)
Gene: ORC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.814

Property	Details
Experiments	31160578, 30804502, 34581668
Identification Methods	affinity chromatography technology, unspecified method
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	BAH~CENP-T_C
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 861
+	Sc
		356161 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SIR3_YEAST (122-810): 1.25e-104: 347: 15.62
+	Hs
		917812 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CDC6_HUMAN (341-861): 4.3e-99: 321: 22.38
+	At
		287544 H4_ARATH (1-103): 3.47e-48: 150: 98.06		CDC6A_ARATH (405-860): 5.01e-90: 296: 22.29
+	Sc
		356645 H4_YEAST (18-103): 6.13e-41: 132: 90.70		ORC1_YEAST (257-861): 5.55e-80: 279: 22.63
+	Hs
		217791 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		ORC4_HUMAN (469-859): 1.67e-73: 249: 17.42
+	Zm
		23744 A0A1D6IAU4_MAIZE (1-103): 4.97e-53: 163: 98.06		B4FBJ7_MAIZE (356-763): 1.87e-68: 235: 13.27
+	Sc
		356648 H4_YEAST (18-103): 6.13e-41: 132: 90.70		ORC4_YEAST (441-831): 1.73e-51: 190: 12.78