HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: SHPRH (Q149N8)
E3 ubiquitin-protein ligase SHPRH (EC 2.3.2.27) (EC 3.6.4.-) (RING-type E3 ubiquitin transferase SHPRH) (SNF2, histone-linker, PHD and RING finger domain-containing helicase)
Gene: SHPRH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	31434570, 28514442, 33961781
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~Helicase_C, CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0000786 - nucleosome GO:0003677 - DNA binding GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1683
+	Hs
		229352 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SMCA5_HUMAN (1267-1682): 2.48e-107: 370: 15.44
+	Hs
		917182 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD3_HUMAN (1279-1682): 6.88e-103: 368: 17.87
+	Hs
		918062 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD7_HUMAN (1187-1679): 3.9e-96: 348: 13.11
+	Hs
		846914 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SMCA4_HUMAN (1246-1682): 3.38e-96: 346: 13.91
+	Hs
		917277 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD4_HUMAN (1275-1682): 1.8e-95: 345: 17.70
+	Hs
		917635 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD6_HUMAN (1133-1679): 1.42e-94: 343: 13.21
+	Hs
		917965 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD8_HUMAN (1145-1679): 9.94e-95: 343: 13.11
+	Hs
		917364 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD9_HUMAN (1288-1679): 4.57e-91: 331: 15.88
+	Hs
		151483 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD2_HUMAN (1248-1682): 9.6e-82: 301: 15.40
+	Sc
		356248 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SNF2_YEAST (1248-1682): 2.06e-82: 303: 14.45
+	Hs
		917476 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SRCAP_HUMAN (1476-1675): 2.89e-61: 235: 18.63
+	Sc
		356309 H4_YEAST (18-103): 6.13e-41: 132: 90.70		RAD16_YEAST (709-987): 3.73e-64: 236: 20.13
+	Hs
		918143 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		TTF2_HUMAN (1507-1675): 3.08e-52: 204: 27.75
+	Sc
		356744 H4_YEAST (18-103): 6.13e-41: 132: 90.70		IRC20_YEAST (1407-1644): 1.69e-51: 202: 26.03
+	Hs
		918003 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HELLS_HUMAN (689-1006): 1.51e-25: 117: 15.67
+	Hs
		917261 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HLTF_HUMAN (265-390): 1.24e-10: 68.6: 28.57
+	Sp
		194289 H4_SCHPO (18-103): 4.87e-42: 135: 89.54		FFT3_SCHPO (1516-1663): 1.54e-12: 74.7: 32.90
+	Sc
		356315 H4_YEAST (18-103): 6.13e-41: 132: 90.70		BTAF1_YEAST (1499-1675): 1.74e-12: 75.1: 30.98