HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: SETB1 (Q15047)
Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)
Gene: SETDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	11959841, 32814053
Identification Methods	pull down, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1291
+	Hs
		917944 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EHMT1_HUMAN (995-1287): 5.59e-70: 259: 21.27
+	Hs
		917760 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EHMT2_HUMAN (999-1287): 2.75e-64: 241: 19.11
+	Hs
		917878 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SETD2_HUMAN (911-1290): 1.29e-53: 209: 16.00
+	Hs
		917621 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2C_HUMAN (1060-1290): 1.71e-53: 208: 23.27
+	Hs
		917338 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EZH2_HUMAN (1026-1272): 1.18e-48: 188: 13.13
+	Zm
		21888 B4FD59_MAIZE (1-103): 3.47e-48: 150: 98.06		A0A1D6HY77_MAIZE (1156-1267): 4.78e-17: 88.7: 22.22
+	Hs
		917987 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT5A_HUMAN (811-916): 4.51e-15: 80.7: 17.39