HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	30804502, 21443952
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 975
+	Hs
		256236 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		BRE1B_HUMAN (1-974): 4.61e-62: 230: 56.49
+	Sc
		356753 H4_YEAST (18-103): 6.13e-41: 132: 90.70		BRE1_YEAST (509-974): 2.63e-58: 215: 19.14
+	Hs
		724750 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		MYH9_HUMAN (235-957): 1.06e-32: 139: 11.26
+	Hs
		528404 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		MYH8_HUMAN (2-685): 1.91e-24: 112: 9.30
+	Sc
		356275 H4_YEAST (18-103): 6.13e-41: 132: 90.70		USO1_YEAST (39-860): 3.87e-28: 125: 13.11
+	Hs
		728462 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		MYH11_HUMAN (586-956): 8.4e-15: 81.7: 11.61
+	Hs
		148635 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		725132 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		MYH10_HUMAN (604-944): 1.39e-12: 74.4: 10.85
+	Hs
		551658 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		DESP_HUMAN (225-919): 9.01e-12: 71.9: 16.12
+	Hs
		502906 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		MYH3_HUMAN (528-953): 5.64e-11: 69: 11.94
+	Mm
		93549 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		DESP_MOUSE (225-904): 1.04e-10: 68.4: 16.67
+	Hs
		917676 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		MY18A_HUMAN (326-919): 1.43e-10: 67.7: 15.69
+	Hs
		149202 H4G_HUMAN (1-98): 1.04e-38: 126: 84.69		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94