HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: NSD1 (Q96L73)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)
Gene: NSD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	30804502, 24412544, 25494638, 21806967
Identification Methods	affinity chromatography technology, enzymatic study, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 2696
+	Hs
		331767 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		917944 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		917878 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SETD2_HUMAN (1790-2119): 9.55e-63: 241: 27.98
+	Hs
		917760 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Hs
		917879 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Sc
		356561 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SET2_YEAST (1828-2091): 1.08e-67: 247: 31.85
+	Hs
		917338 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Sc
		356466 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SET1_YEAST (1936-2081): 1.38e-20: 102: 39.19
+	Hs
		917621 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		152623 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2D_HUMAN (1011-1538): 2.41e-09: 65.8: 8.69