HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	25494638, 30804502
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CENP-T_C~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1437
+	Hs
		331767 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		917760 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		917878 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		917944 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		917338 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Sc
		356466 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SET1_YEAST (1012-1284): 2.3e-61: 232: 25.41
+	Sc
		356561 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SET2_YEAST (1020-1303): 1.42e-60: 224: 29.41
+	Hs
		917145 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		917762 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		917621 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2C_HUMAN (1278-1411): 2.31e-13: 77.9: 15.75
+	Hs
		918135 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83