HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	35676659, 21090589, 10220385
Identification Methods	affinity chromatography technology, unspecified method, deacetylase assay
Interaction Type	physical association, direct interaction, deacetylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1215
+	Mm
		140249 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		HDAC1_MOUSE (80-482): 2.38e-166: 504: 20.94
+	Hs
		917226 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Dm
		950398 H4_DROME (1-103): 4.51e-48: 150: 99.03		HDAC1_DROME (79-483): 6.2e-159: 486: 19.01
+	Hs
		917682 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Mm
		918237 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		HDAC2_MOUSE (78-489): 8.71e-157: 479: 21.02
+	Hs
		880666 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC4_HUMAN (405-873): 1.97e-147: 474: 36.51
+	Hs
		918151 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		177252 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC3_HUMAN (479-890): 6.6e-146: 448: 18.29
+	Sc
		356643 H4_YEAST (18-103): 6.13e-41: 132: 90.70		HDA1_YEAST (80-456): 4.66e-148: 464: 33.17
+	Hs
		918121 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC9_HUMAN (7-432): 5.62e-136: 441: 33.19
+	Sc
		356336 H4_YEAST (18-103): 6.13e-41: 132: 90.70		RPD3_YEAST (75-473): 1.1e-149: 458: 20.24
+	Hs
		917872 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC8_HUMAN (103-388): 4.42e-19: 92.8: 26.67