HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: INO80 (Q9ULG1)
Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A)
Gene: INO80

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	27248496, 30804502, 19014934
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~Helicase_C, CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1556
+	Sc
		356605 H4_YEAST (18-103): 6.13e-41: 132: 90.70		INO80_YEAST (132-1282): 0: 710: 36.89
+	Sc
		356721 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SWR1_YEAST (251-1353): 0: 640: 25.93
+	Hs
		917965 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD8_HUMAN (848-1407): 6.68e-106: 377: 19.73
+	Hs
		918062 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD7_HUMAN (884-1398): 1.5e-105: 376: 21.24
+	Hs
		917635 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD6_HUMAN (916-1408): 4.36e-104: 372: 23.06
+	Hs
		917182 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD3_HUMAN (911-1457): 4.26e-103: 368: 21.48
+	Hs
		917277 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD4_HUMAN (918-1457): 1.22e-101: 363: 22.08
+	Hs
		917364 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD9_HUMAN (848-1396): 1.01e-99: 358: 20.62
+	Hs
		846914 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SMCA4_HUMAN (767-1442): 3.46e-100: 357: 16.87
+	Hs
		151483 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		CHD2_HUMAN (909-1437): 1.11e-86: 316: 23.46
+	Hs
		229352 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SMCA5_HUMAN (992-1344): 2.3e-82: 296: 34.18
+	Hs
		917476 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		SRCAP_HUMAN (990-1495): 3.81e-76: 283: 27.33
+	Sc
		356350 H4_YEAST (18-103): 6.13e-41: 132: 90.70		CHD1_YEAST (998-1386): 1.4e-64: 244: 28.93
+	Sc
		356774 H4_YEAST (18-103): 6.13e-41: 132: 90.70		ISW2_YEAST (1094-1255): 2.43e-43: 175: 53.99
+	Sc
		356248 H4_YEAST (18-103): 6.13e-41: 132: 90.70		SNF2_YEAST (1100-1319): 1.02e-37: 157: 41.56
+	Sc
		356424 H4_YEAST (18-103): 6.13e-41: 132: 90.70		ISW1_YEAST (1116-1263): 1.28e-36: 153: 51.68