HitPredict

Interactor 1: H4 (P62805)
Histone H4
Gene: H4C1

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	21081666, 10220385
Identification Methods	affinity chromatography technology, deacetylase assay
Interaction Type	physical association, deacetylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 103 Hs			1 1122
+	Hs
		880666 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		918121 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC9_HUMAN (25-1055): 0: 608: 56.33
+	Mm
		140249 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		HDAC1_MOUSE (673-1103): 1.61e-153: 468: 21.16
+	Hs
		917226 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		917682 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Mm
		918237 H4_MOUSE (1-103): 1.38e-48: 151: 100.00		HDAC2_MOUSE (680-1113): 4.65e-153: 467: 21.68
+	Dm
		950398 H4_DROME (1-103): 4.51e-48: 150: 99.03		HDAC1_DROME (676-1113): 4.3e-153: 468: 21.93
+	Hs
		177252 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Sc
		356336 H4_YEAST (18-103): 6.13e-41: 132: 90.70		RPD3_YEAST (665-1098): 4.72e-146: 446: 22.00
+	Sc
		356643 H4_YEAST (18-103): 6.13e-41: 132: 90.70		HDA1_YEAST (658-1097): 4.56e-140: 441: 32.32
+	Hs
		918077 H4_HUMAN (1-103): 1.38e-48: 151: 100.00		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Sc
		356604 H4_YEAST (18-103): 6.13e-41: 132: 90.70		HOS2_YEAST (704-1005): 7.92e-24: 108: 28.39