HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	34079125, 21888893
Identification Methods	proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 185
+	Hs
		1027018 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		241519 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		420833 H2B1J_HUMAN (1-126): 6.62e-54: 166: 98.41		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		918334 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		420825 H2B1J_HUMAN (1-126): 6.62e-54: 166: 98.41		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Hs
		949797 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Hs
		241469 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		800336 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		800398 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		203602 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10
+	Hs
		1059155 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		CBX2_HUMAN (10-110): 2.55e-25: 103: 29.70
+	Hs
		1087494 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		CDYL_HUMAN (7-120): 2.53e-25: 103: 25.86
+	Hs
		316041 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		CBX6_HUMAN (12-101): 1.25e-25: 103: 30.00
+	Hs
		918366 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		CBX2_HUMAN (10-110): 2.55e-25: 103: 29.70
+	Hs
		918778 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		CDYL_HUMAN (7-120): 2.53e-25: 103: 25.86
+	Hs
		123222 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		CBX4_HUMAN (12-89): 1e-24: 101: 34.62
+	Hs
		123255 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		CBX4_HUMAN (12-89): 1e-24: 101: 34.62
+	Hs
		1087415 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		CBX8_HUMAN (12-88): 1.45e-24: 100: 35.07
+	Hs
		241642 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		CBX8_HUMAN (12-88): 1.45e-24: 100: 35.07
+	Hs
		918703 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		CBX8_HUMAN (12-88): 1.45e-24: 100: 35.07