HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	25281560, 34079125, 34349018
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 3969
+	Hs
		241509 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		975269 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		707596 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		1087483 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		918772 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		1079994 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1080205 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		241535 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		918389 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		203602 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Hs
		1274453 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		ASH1L_HUMAN (3266-3968): 1.46e-72: 275: 14.78
+	Hs
		331768 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		331825 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		1087385 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		918663 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		165638 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		918533 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		707690 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		918628 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18
+	Hs
		152598 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47