HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: CENPC (Q03188)
Centromere protein C (CENP-C) (Centromere autoantigen C) (Centromere protein C 1) (CENP-C 1) (Interphase centromere complex protein 7)
Gene: CENPC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25281560, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CENP-C_mid~Histone
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 943
+	Mm
		828448 H2B1A_MOUSE (1-126): 2.94e-50: 157: 87.40		CENPC_MOUSE (1-943): 1.36e-146: 459: 49.95
+	Hs
		1087196 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		NIPBL_HUMAN (32-885): 3.58e-111: 380: 14.35
+	Hs
		918442 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		NIPBL_HUMAN (32-885): 3.58e-111: 380: 14.35
+	Sc
		355857 H2B2_YEAST (3-125): 5.51e-37: 124: 71.55		CENPC_YEAST (698-941): 4.33e-33: 137: 17.31
+	Sc
		355439 H2B1_YEAST (3-125): 1.92e-36: 122: 71.55		CENPC_YEAST (698-941): 4.33e-33: 137: 17.31
+	Hs
		707767 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		MDN1_HUMAN (226-943): 1.44e-11: 71.1: 10.74
+	Hs
		1129830 H2B2F_HUMAN (1-126): 2.21e-54: 168: 98.41		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55
+	Hs
		617962 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55
+	Hs
		1087299 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55
+	Hs
		1264778 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55
+	Hs
		241595 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55
+	Hs
		883041 H2BFS_HUMAN (1-126): 1.03e-53: 166: 97.62		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55
+	Hs
		918561 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55
+	Hs
		886166 H2B1D_HUMAN (1-126): 3.24e-53: 164: 99.21		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55
+	Hs
		1264792 H2B1L_HUMAN (1-126): 2.18e-52: 163: 98.41		TITIN_HUMAN (74-845): 1.85e-10: 67.6: 10.55