HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 406
+	Hs
		707600 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		1087359 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		918631 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		707723 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		1231231 H2B3B_HUMAN (1-126): 8.29e-52: 161: 95.24		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		717646 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		717877 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		707534 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		717607 H2B1D_HUMAN (1-126): 3.24e-53: 164: 99.21		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		1087364 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		718401 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37
+	Hs
		918638 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		707725 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		BARD1_HUMAN (4-335): 2.56e-39: 151: 13.35
+	Hs
		1087375 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		918649 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		749336 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		749545 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		707539 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Mm
		1145466 H2B2E_MOUSE (1-126): 1.08e-52: 163: 96.03		CHFR_MOUSE (24-278): 1.38e-34: 137: 15.69