HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: H2A2A (Q6FI13)
Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o)
Gene: H2AC18

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	25281560, 34079125, 34349018, 37071682
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 130
+	Hs
		1151403 U3KQK0_HUMAN (1-126): 3.61e-55: 171: 99.21		H2A2A_HUMAN (1-130): 4.66e-67: 200: 100.00
+	Hs
		391992 U3KQK0_HUMAN (1-126): 3.61e-55: 171: 99.21		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		391736 H2B2F_HUMAN (1-126): 2.21e-54: 168: 98.41		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		470411 H2B2F_HUMAN (1-126): 2.21e-54: 168: 98.41		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		617952 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		H2A2A_HUMAN (1-130): 4.66e-67: 200: 100.00
+	Hs
		391552 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		391868 H2B1M_HUMAN (1-126): 4.46e-54: 167: 96.83		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		420844 H2B1J_HUMAN (1-126): 6.62e-54: 166: 98.41		H2A2A_HUMAN (1-130): 4.66e-67: 200: 100.00
+	Hs
		470271 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		594822 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		H2A1D_HUMAN (1-130): 7.72e-67: 199: 97.69
+	Hs
		1307102 H2B1M_HUMAN (1-126): 4.46e-54: 167: 96.83		H2A1J_HUMAN (1-128): 2.76e-66: 198: 97.66
+	Hs
		391503 H2B1J_HUMAN (1-126): 6.62e-54: 166: 98.41		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		420794 H2B1J_HUMAN (1-126): 6.62e-54: 166: 98.41		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		420804 H2B1J_HUMAN (1-126): 6.62e-54: 166: 98.41		H2A1D_HUMAN (1-130): 7.72e-67: 199: 97.69
+	Hs
		617950 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		H2A2C_HUMAN (1-128): 2.7e-64: 193: 96.88
+	Hs
		617974 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		H2AJ_HUMAN (1-128): 2.61e-64: 193: 94.53
+	Hs
		555496 H2B2F_HUMAN (1-126): 2.21e-54: 168: 98.41		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Hs
		555295 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Hs
		555619 H2B1M_HUMAN (1-126): 4.46e-54: 167: 96.83		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Hs
		420800 H2B1J_HUMAN (1-126): 6.62e-54: 166: 98.41		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81