HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 4374
+	Hs
		1087225 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		241572 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		886146 H2B1D_HUMAN (1-126): 3.24e-53: 164: 99.21		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		1192122 H2B3B_HUMAN (1-126): 8.29e-52: 161: 95.24		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		125494 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		125676 H2B1N_HUMAN (1-126): 3e-53: 164: 99.21		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		1087416 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Sc
		355609 H2B1_YEAST (3-125): 1.92e-36: 122: 71.55		TOM1_YEAST (3831-4374): 1.99e-157: 554: 43.77