HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25281560, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 1437
+	Hs
		331768 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		331825 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		855491 H2B2F_HUMAN (1-126): 2.21e-54: 168: 98.41		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		855449 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		855488 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		203602 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		1274453 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		ASH1L_HUMAN (1002-1314): 3.35e-61: 234: 29.85
+	Hs
		918611 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		918699 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		1079994 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1080205 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		241535 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		918389 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		241509 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		918303 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		975269 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		1274410 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		918612 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		918533 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		KMT2C_HUMAN (1278-1411): 2.31e-13: 77.9: 15.75
+	Hs
		918772 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83