HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: PARP2 (Q9UGN5)
Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)
Gene: PARP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	28190768, 25281560, 33961781
Identification Methods	enzymatic study, proximity labelling technology, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 583
+	Hs
		1087460 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		PARP2_HUMAN (16-583): 0: 739: 100.00
+	Hs
		707781 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		PARP2_HUMAN (16-583): 0: 739: 100.00
+	Hs
		1231259 H2B3B_HUMAN (1-126): 8.29e-52: 161: 95.24		PARP2_HUMAN (16-583): 0: 739: 100.00
+	Hs
		1282979 H2B1A_HUMAN (1-126): 3.14e-46: 147: 84.25		PARP2_HUMAN (16-583): 0: 739: 100.00
+	Hs
		455094 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455301 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455500 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455733 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455136 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455276 H2B1D_HUMAN (1-126): 3.24e-53: 164: 99.21		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455645 H2B3B_HUMAN (1-126): 8.29e-52: 161: 95.24		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Hs
		455738 H2B1A_HUMAN (1-126): 3.14e-46: 147: 84.25		PARP1_HUMAN (15-583): 0: 681: 37.91
+	Dm
		355257 H2B_DROME (36-126): 9.18e-47: 148: 94.51		PARP_DROME (53-579): 0: 599: 38.80
+	Hs
		1087515 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		PARP3_HUMAN (51-577): 3.66e-168: 490: 34.31
+	Hs
		617984 H2B1O_HUMAN (1-126): 2.88e-54: 167: 98.41		PARP4_HUMAN (37-577): 2.15e-126: 409: 20.14
+	Hs
		1274474 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		PARP4_HUMAN (37-577): 2.15e-126: 409: 20.14
+	Hs
		241659 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		PARP4_HUMAN (37-577): 2.15e-126: 409: 20.14