HitPredict

Interactor 1: H2B1C (P62807)
Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)
Gene: H2BC4

Interactor 2: KMT2B (Q9UMN6)
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
Gene: KMT2B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 2715
+	Hs
		1087483 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		KMT2B_HUMAN (1-2715): 0: 1040: 100.00
+	Hs
		203602 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		SUV91_HUMAN (2388-2714): 1.13e-72: 252: 18.21
+	Hs
		1274453 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		ASH1L_HUMAN (2005-2714): 1.99e-64: 247: 11.96
+	Hs
		1079994 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Hs
		1080205 H2B1H_HUMAN (1-126): 5.49e-54: 166: 99.21		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Hs
		241535 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Hs
		918389 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		EZH2_HUMAN (2246-2697): 1.88e-65: 241: 16.76
+	Hs
		241509 H2B1K_HUMAN (1-126): 1.3e-53: 166: 99.21		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		918303 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		975269 H2B2E_HUMAN (1-126): 5.61e-54: 166: 99.21		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Sp
		223810 H2B1_SCHPO (4-125): 1.06e-45: 146: 70.49		CLR4_SCHPO (2299-2714): 8.14e-65: 231: 18.57
+	Hs
		707596 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		886089 H2B1D_HUMAN (1-126): 3.24e-53: 164: 99.21		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		975314 H2B1L_HUMAN (1-126): 2.18e-52: 163: 98.41		KMT2A_HUMAN (1779-2715): 1.14e-53: 212: 30.49
+	Hs
		918501 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		PHF6_HUMAN (1573-1755): 1.92e-32: 133: 19.12
+	Hs
		707682 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		PHF6_HUMAN (1573-1755): 1.92e-32: 133: 19.12
+	Hs
		165638 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		SET1A_HUMAN (2571-2715): 1.52e-26: 122: 52.74
+	Hs
		152598 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		KMT2D_HUMAN (396-778): 9.23e-10: 67.2: 20.80
+	Hs
		918533 H2B1C_HUMAN (1-126): 1.05e-53: 166: 100.00		KMT2C_HUMAN (2005-2475): 4.5e-09: 64.8: 11.39
+	Hs
		707690 H2B1B_HUMAN (1-126): 1.52e-53: 165: 97.62		KMT2C_HUMAN (2005-2475): 4.5e-09: 64.8: 11.39