HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: RGPD4 (Q7Z3J3)
RanBP2-like and GRIP domain-containing protein 4
Gene: RGPD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Rab_bind~Ras, Ran_BP1~Ras, Ras~TPR_8
Common GO terms	GO:0005643 - nuclear pore GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 1758
+	Hs
		63882 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD3_HUMAN (1-1758): 0: 2400: 98.29
+	Hs
		152774 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD8_HUMAN (1-1758): 0: 2363: 95.05
+	Hs
		483422 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD2_HUMAN (1-1756): 0: 2334: 95.44
+	Hs
		483392 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RGPD1_HUMAN (24-1756): 0: 2314: 95.56
+	Sc
		698833 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		NU159_YEAST (777-1693): 2.78e-90: 326: 13.90
+	At
		784994 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		RBP1A_ARATH (1014-1240): 3.44e-38: 145: 25.99
+	At
		784989 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		RBP1B_ARATH (1011-1228): 5.52e-37: 141: 30.46
+	Ce
		184992 RAN_CAEEL (3-205): 3.44e-97: 283: 88.18		Q21021_CAEEL (798-1466): 7.9e-31: 134: 17.78
+	Ce
		184995 RAN_CAEEL (3-205): 3.44e-97: 283: 88.18		Q86G90_CAEEL (1140-1466): 2.74e-30: 132: 25.53
+	At
		785000 RAN2_ARATH (1-215): 1.36e-88: 261: 74.77		RBP1A_ARATH (1014-1240): 3.44e-38: 145: 25.99
+	Sc
		691616 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		NUP2_YEAST (766-1172): 1.22e-38: 158: 17.26
+	Sc
		698847 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		YRB1_YEAST (1287-1471): 4.87e-42: 155: 38.17
+	At
		784991 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		NU50A_ARATH (791-1196): 1.16e-28: 123: 18.75
+	At
		784998 RAN2_ARATH (1-215): 1.36e-88: 261: 74.77		RBP1B_ARATH (1011-1228): 5.52e-37: 141: 30.46
+	Sp
		660086 SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84		RANG_SCHPO (1264-1470): 6e-39: 146: 34.12
+	At
		1210455 RAN3_ARATH (1-215): 9.1e-84: 249: 74.31		RBP1A_ARATH (1014-1240): 3.44e-38: 145: 25.99
+	At
		1210453 RAN3_ARATH (1-215): 9.1e-84: 249: 74.31		RBP1B_ARATH (1011-1228): 5.52e-37: 141: 30.46
+	Hs
		796725 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		RANG_HUMAN (1015-1208): 1.13e-38: 145: 37.37
+	Xl
		193796 RAN_XENLA (1-216): 7.81e-80: 239: 98.15		O42193_XENLA (1014-1218): 6.08e-36: 138: 35.10
+	Sc
		698835 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		YRB2_YEAST (894-1170): 1.19e-31: 129: 19.19