HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: RAB2B (Q8WUD1)
Ras-related protein Rab-2B (EC 3.6.5.2)
Gene: RAB2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 216
+	Mm
		895595 RAB35_MOUSE (6-188): 1.31e-87: 258: 29.19		RAB8B_MOUSE (2-198): 3.07e-97: 283: 45.69
+	Ce
		185001 RAN_CAEEL (3-205): 3.44e-97: 283: 88.18		Q9UAQ6_CAEEL (3-216): 1.82e-85: 253: 43.93
+	Hs
		918916 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		RAB2B_HUMAN (1-216): 1.82e-92: 271: 100.00
+	Hs
		895084 RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19		RAB2A_HUMAN (1-216): 2.31e-86: 256: 82.87
+	Zm
		73944 B4FAE1_MAIZE (4-208): 1.07e-84: 251: 27.89		B4FAE1_MAIZE (3-216): 1.52e-86: 256: 45.79
+	Hs
		918874 RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19		RAB1A_HUMAN (3-216): 9.52e-84: 249: 43.93
+	Mm
		918986 RAB35_MOUSE (6-188): 1.31e-87: 258: 29.19		RAB1A_MOUSE (3-216): 9.52e-84: 249: 43.93
+	Hs
		895216 RAB1C_HUMAN (7-195): 2.28e-83: 247: 28.13		RAB2A_HUMAN (1-216): 2.31e-86: 256: 82.87
+	Mm
		1161509 RAB35_MOUSE (6-188): 1.31e-87: 258: 29.19		RAB1B_MOUSE (3-216): 3.66e-82: 244: 42.52
+	Hs
		895026 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		RAB2A_HUMAN (1-216): 2.31e-86: 256: 82.87
+	Mm
		895587 RAB10_MOUSE (3-177): 1.29e-85: 253: 30.90		RAB1B_MOUSE (3-216): 3.66e-82: 244: 42.52
+	Sc
		350875 YPT1_YEAST (4-187): 6.68e-83: 247: 26.74		YPT31_YEAST (2-216): 1.23e-82: 246: 41.86
+	Hs
		918846 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		RAB1A_HUMAN (3-216): 9.52e-84: 249: 43.93
+	Hs
		896605 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		RAB14_HUMAN (3-215): 4.02e-82: 245: 55.87
+	Hs
		918944 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		RAB1B_HUMAN (3-216): 1.37e-82: 245: 42.52
+	Hs
		918879 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		RB11B_HUMAN (3-216): 7.59e-82: 244: 46.73
+	Mm
		919000 RAB1A_MOUSE (1-196): 3.67e-82: 244: 28.00		RAB1B_MOUSE (3-216): 3.66e-82: 244: 42.52
+	Hs
		913992 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		RB11A_HUMAN (3-216): 1.65e-81: 243: 46.26
+	Hs
		591801 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		RAB4A_HUMAN (2-188): 8.55e-74: 224: 58.29
+	Hs
		894715 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		RAB8A_HUMAN (2-196): 8.26e-61: 190: 46.19