HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33545068
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 577
+	Hs
		1287377 RAB1B_HUMAN (4-195): 1.12e-80: 240: 28.72		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		894791 RAB8A_HUMAN (1-203): 1.27e-79: 238: 24.76		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		914277 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		OPTN_HUMAN (1-577): 2.87e-50: 184: 100.00
+	Hs
		894836 RAB8A_HUMAN (1-203): 1.27e-79: 238: 24.76		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		919322 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		NEMO_HUMAN (204-576): 1.98e-39: 150: 25.86
+	Hs
		1070208 RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		1051283 RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		894733 RAB8A_HUMAN (1-203): 1.27e-79: 238: 24.76		DCTN1_HUMAN (199-553): 3.22e-27: 119: 17.58
+	Hs
		914091 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		ITSN1_HUMAN (160-551): 1.63e-27: 120: 14.90
+	Hs
		1070216 RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		148636 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		1070480 RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19		MRCKB_HUMAN (39-409): 3.06e-09: 62.4: 14.77
+	Hs
		149274 RAB1B_HUMAN (4-195): 1.12e-80: 240: 28.72		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		919078 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		NUMA1_HUMAN (4-572): 1.29e-14: 79.5: 12.87
+	Hs
		919096 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		148637 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		CTRO_HUMAN (7-564): 1.03e-13: 76.6: 11.59
+	Hs
		914103 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		GRDN_HUMAN (5-456): 8.11e-14: 77.2: 9.37
+	Hs
		894813 RAB8A_HUMAN (1-203): 1.27e-79: 238: 24.76		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		914383 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		MYO5C_HUMAN (39-462): 1.18e-12: 73.1: 14.87
+	Hs
		254466 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		ROCK2_HUMAN (1-323): 2.95e-11: 68.7: 10.22