HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: IPO9 (Q96P70)
Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9)
Gene: IPO9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	28514442, 35271311, 27114554
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	IBN_N~Ras
Common GO terms	GO:0005635 - nuclear envelope GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006606 - protein import into nucleus GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 216 Hs			1 1041
+	Hs
		312234 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IPO7_HUMAN (22-1040): 2.16e-162: 507: 14.21
+	Dm
		1373317 RANL_DROME (1-210): 2.56e-93: 273: 60.48		Q9VRV8_DROME (13-878): 4.95e-147: 463: 12.88
+	Hs
		178143 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IPO8_HUMAN (25-1039): 3.25e-157: 494: 14.66
+	Hs
		919198 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		TNPO1_HUMAN (14-878): 2.66e-148: 466: 12.42
+	At
		784988 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		TNPO1_ARATH (8-873): 6.18e-129: 415: 14.30
+	Hs
		874484 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		XPO2_HUMAN (17-882): 4.31e-144: 457: 14.30
+	Hs
		155560 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		TNPO2_HUMAN (14-878): 1.92e-140: 445: 13.05
+	Sp
		142272 SPI1_SCHPO (1-214): 1.23e-84: 251: 80.84		CSE1_SCHPO (23-897): 2.3e-124: 405: 12.75
+	Sc
		698878 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		IMB5_YEAST (23-1038): 8.56e-125: 407: 18.95
+	Sc
		698861 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		NMD5_YEAST (24-1029): 6.9e-121: 398: 14.47
+	At
		784992 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		IMB1_ARATH (21-800): 1.96e-108: 360: 14.71
+	Sc
		698750 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		CSE1_YEAST (34-876): 2.52e-113: 375: 13.03
+	At
		784999 RAN2_ARATH (1-215): 1.36e-88: 261: 74.77		IMB1_ARATH (21-800): 1.96e-108: 360: 14.71
+	Sc
		698999 GSP2_YEAST (1-214): 1.18e-80: 241: 79.72		CSE1_YEAST (34-876): 2.52e-113: 375: 13.03
+	Sc
		698930 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		SXM1_YEAST (22-898): 1.29e-109: 364: 14.35
+	At
		1210454 RAN3_ARATH (1-215): 9.1e-84: 249: 74.31		IMB1_ARATH (21-800): 1.96e-108: 360: 14.71
+	Hs
		162599 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		XPO1_HUMAN (1-923): 1.59e-108: 365: 10.42
+	Hs
		919077 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IMB1_HUMAN (23-911): 6.16e-109: 361: 13.37
+	Sc
		698917 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		KA120_YEAST (25-905): 4.17e-22: 105: 14.05
+	Sc
		699016 GSP2_YEAST (1-214): 1.18e-80: 241: 79.72		KA120_YEAST (25-905): 4.17e-22: 105: 14.05