HitPredict

Interactor 1: RAN (P62826)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: XPO7 (Q9UIA9)
Exportin-7 (Exp7) (Ran-binding protein 16)
Gene: XPO7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	32296183, 11024021, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, pull down, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	IBN_N~Ras
Common GO terms	GO:0005634 - nucleus GO:0005643 - nuclear pore GO:0005737 - cytoplasm GO:0006611 - protein export from nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 216 Hs			1 1087
+	Hs
		162599 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		XPO1_HUMAN (7-1074): 0: 815: 13.35
+	Sc
		675912 GSP1_YEAST (1-214): 5.23e-83: 247: 80.56		XPO1_YEAST (7-1073): 0: 775: 14.80
+	Hs
		919258 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		XPO4_HUMAN (4-1073): 0: 665: 17.43
+	At
		784987 RAN1_ARATH (1-216): 1.39e-95: 279: 73.52		MOS14_ARATH (5-543): 2.51e-42: 170: 13.04
+	Hs
		919273 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		XPO5_HUMAN (6-239): 7.13e-43: 172: 15.14
+	Hs
		914368 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		XPO5_HUMAN (6-239): 7.13e-43: 172: 15.14
+	Hs
		919228 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		XPO6_HUMAN (1-1083): 1.49e-33: 142: 11.62
+	Hs
		297168 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		IPO13_HUMAN (8-726): 5.88e-15: 81.8: 12.82
+	Hs
		207921 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		XPOT_HUMAN (12-229): 2.94e-11: 69.9: 13.84