HitPredict

Interactor 1: RAN (P62827)
GTP-binding nuclear protein Ran (EC 3.6.5.-) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
Gene: RAN

Interactor 2: TSC1 (Q9EP53)
Hamartin (Tuberous sclerosis 1 protein homolog)
Gene: TSC1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000054 - ribosomal subunit export from nucleus GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0021766 - hippocampus development
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 216 Mm			1 1161
+	Hs
		914256 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		TSC1_HUMAN (1-1161): 0: 767: 86.98
+	Mm
		845410 RAB7A_MOUSE (8-166): 7.44e-29: 108: 33.13		TSC1_MOUSE (1-1161): 0: 771: 100.00
+	Hs
		845125 RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13		TSC1_HUMAN (1-1161): 0: 767: 86.98
+	Hs
		591957 RAB4A_HUMAN (11-169): 1.53e-27: 105: 34.57		TSC1_HUMAN (1-1161): 0: 767: 86.98
+	Hs
		148636 RAB1A_HUMAN (1-196): 3.67e-82: 244: 28.00		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		149274 RAB1B_HUMAN (4-195): 1.12e-80: 240: 28.72		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		148637 RAN_HUMAN (1-216): 7.75e-79: 237: 100.00		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		1070238 RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		254466 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		ROCK2_HUMAN (398-1090): 3.16e-25: 116: 12.76
+	Ce
		136547 RAN_CAEEL (3-205): 3.44e-97: 283: 88.18		MRCK_CAEEL (371-771): 7.55e-09: 62.5: 9.09
+	Hs
		1070480 RAB35_HUMAN (6-188): 1.31e-87: 258: 29.19		MRCKB_HUMAN (421-862): 5.66e-16: 85.6: 11.45
+	Hs
		914124 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		914285 RB11A_HUMAN (4-207): 7.68e-78: 234: 25.94		KI16B_HUMAN (692-962): 9.32e-09: 62.1: 14.77
+	Hs
		148600 RAB10_HUMAN (11-177): 3.9e-29: 109: 33.14		CTRO_HUMAN (326-1095): 8.06e-30: 131: 10.51
+	Hs
		844984 RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13		MRCKA_HUMAN (487-978): 2.97e-23: 109: 12.91
+	Hs
		591852 RAB4A_HUMAN (11-169): 1.53e-27: 105: 34.57		EEA1_HUMAN (408-851): 3.09e-13: 76.8: 8.35
+	Hs
		845174 RAB7A_HUMAN (8-166): 7.44e-29: 108: 33.13		KI16B_HUMAN (692-962): 9.32e-09: 62.1: 14.77
+	Hs
		591979 RAB4A_HUMAN (11-169): 1.53e-27: 105: 34.57		KI16B_HUMAN (692-962): 9.32e-09: 62.1: 14.77