HitPredict

Interactor 1: RL23 (P62829)
Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23)
Gene: RPL23

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.744

The method score is based on:

Property	Details
Experiments	15314173, 15308643, 17116689, 23169665, 20547751, 17110929, 17310983
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005829 - cytosol and 5 others more... GO:0008284 - positive regulation of cell population proliferation GO:0010628 - positive regulation of gene expression GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0072717 - cellular response to actinomycin D
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	140
Hs

1	491

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024