HitPredict

Interactor 1: RAP1A (P62834)
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Gene: RAP1A

Interactor 2: RGDSR (Q8IZJ4)
Ral-GDS-related protein (hRGR) (Ral guanine nucleotide dissociation stimulator-like 4) (RalGDS-like 4)
Gene: RGL4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12874025
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RasGEF
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 184 Hs			1 473
+	Hs
		897883 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		GNDS_HUMAN (37-472): 6.67e-124: 384: 40.04
+	Hs
		919618 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		GNDS_HUMAN (37-472): 6.67e-124: 384: 40.04
+	Hs
		897981 RAP2B_HUMAN (1-166): 9.28e-65: 198: 66.27		GNDS_HUMAN (37-472): 6.67e-124: 384: 40.04
+	Hs
		171541 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		RGL2_HUMAN (82-471): 1.97e-102: 324: 28.05
+	Hs
		171545 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RGL2_HUMAN (82-471): 1.97e-102: 324: 28.05
+	Hs
		897964 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		RGL1_HUMAN (82-469): 6.82e-97: 310: 32.13
+	Dm
		442959 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q86BI2_DROME (60-473): 3.24e-89: 290: 26.51
+	Dm
		442968 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q9GR11_DROME (60-473): 4.04e-89: 289: 26.51
+	Dm
		442969 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q9U4U5_DROME (60-473): 2.13e-87: 289: 26.51
+	Hs
		919681 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RGL1_HUMAN (82-469): 6.82e-97: 310: 32.13
+	Hs
		925226 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		SOS1_HUMAN (51-473): 2.48e-85: 287: 19.12
+	Hs
		925267 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RPGF1_HUMAN (85-472): 5.54e-82: 275: 19.44
+	Hs
		919625 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF1_HUMAN (85-472): 5.54e-82: 275: 19.44
+	Hs
		156397 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RGRF2_HUMAN (119-473): 1.01e-78: 268: 19.84
+	Hs
		919653 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF6_HUMAN (96-470): 1.06e-78: 269: 16.08
+	Hs
		919687 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF2_HUMAN (96-470): 2.11e-78: 268: 15.51
+	Hs
		919656 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF4_HUMAN (190-473): 1.96e-75: 257: 16.84
+	Hs
		897984 RAP2B_HUMAN (1-166): 9.28e-65: 198: 66.27		RPGF1_HUMAN (85-472): 5.54e-82: 275: 19.44
+	Hs
		897996 RAP2B_HUMAN (1-166): 9.28e-65: 198: 66.27		RPGF2_HUMAN (96-470): 2.11e-78: 268: 15.51
+	Hs
		919657 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF5_HUMAN (196-471): 1.3e-71: 238: 15.00