HitPredict

Interactor 1: RAP1A (P62834)
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Gene: RAP1A

Interactor 2: RPGF6 (Q8TEU7)
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)
Gene: RAPGEF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 11524421
Identification Methods enzymatic study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PDZ~Ras, RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0031267 - small GTPase binding
GO:0043547 - positive regulation of GTPase activity
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 184
Hs

1 1601
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Last updated: 15 Jul 2024