HitPredict

Interactor 1: RAP1A (P62834)
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Gene: RAP1A

Interactor 2: RPGF4 (Q8WZA2)
Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)
Gene: RAPGEF4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10777494
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0031267 - small GTPase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 184 Hs			1 1011
+	Hs
		919657 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF5_HUMAN (479-1009): 2.18e-147: 453: 45.61
+	Hs
		897883 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		GNDS_HUMAN (498-1009): 1.94e-115: 379: 14.26
+	Hs
		919618 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		GNDS_HUMAN (498-1009): 1.94e-115: 379: 14.26
+	Hs
		156397 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RGRF2_HUMAN (557-1011): 5.8e-105: 357: 17.90
+	Hs
		897981 RAP2B_HUMAN (1-166): 9.28e-65: 198: 66.27		GNDS_HUMAN (498-1009): 1.94e-115: 379: 14.26
+	Dm
		442959 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q86BI2_DROME (530-1011): 1.7e-97: 327: 15.99
+	Dm
		442968 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q9GR11_DROME (530-1011): 1.78e-97: 327: 15.99
+	Dm
		442969 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q9U4U5_DROME (535-1011): 1.16e-94: 323: 15.96
+	Hs
		171541 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		RGL2_HUMAN (610-1009): 1.7e-96: 324: 13.93
+	Hs
		925226 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		SOS1_HUMAN (649-1011): 2.62e-94: 328: 20.37
+	Hs
		171545 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RGL2_HUMAN (610-1009): 1.7e-96: 324: 13.93
+	Hs
		919645 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RGDSR_HUMAN (605-1011): 1.79e-97: 317: 14.19
+	Hs
		919653 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF6_HUMAN (7-651): 1.68e-86: 307: 17.98
+	Hs
		925267 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RPGF1_HUMAN (752-1010): 1.47e-80: 286: 27.86
+	Hs
		919625 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF1_HUMAN (752-1010): 1.47e-80: 286: 27.86
+	Hs
		897984 RAP2B_HUMAN (1-166): 9.28e-65: 198: 66.27		RPGF1_HUMAN (752-1010): 1.47e-80: 286: 27.86
+	Dm
		442976 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q9VMF3_DROME (1-294): 2.48e-43: 174: 13.18
+	Hs
		919687 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF2_HUMAN (15-365): 3.4e-50: 195: 13.95
+	Hs
		313169 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		RPGF3_HUMAN (1-301): 2.15e-40: 163: 20.18
+	Hs
		313171 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF3_HUMAN (1-301): 2.15e-40: 163: 20.18