HitPredict

Interactor 1: RAP1A (P62834)
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Gene: RAP1A

Interactor 2: RPGF5 (Q92565)
Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)
Gene: RAPGEF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	10777494, 10934204
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005886 - plasma membrane GO:0007399 - nervous system development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 184 Hs			1 580
+	Hs
		919656 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF4_HUMAN (60-579): 4.62e-177: 529: 46.39
+	Hs
		313169 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		RPGF3_HUMAN (67-578): 5.04e-163: 490: 36.95
+	Hs
		313171 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF3_HUMAN (67-578): 5.04e-163: 490: 36.95
+	Hs
		313164 RAP2A_HUMAN (1-181): 3.65e-62: 192: 62.43		RPGF3_HUMAN (67-578): 5.04e-163: 490: 36.95
+	Hs
		897883 RAP1B_HUMAN (1-184): 6.73e-77: 229: 95.11		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		919618 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		897981 RAP2B_HUMAN (1-166): 9.28e-65: 198: 66.27		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		486024 RAP2A_HUMAN (1-181): 3.65e-62: 192: 62.43		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		919653 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF6_HUMAN (181-566): 5.18e-100: 334: 26.08
+	Hs
		919687 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF2_HUMAN (182-578): 7.88e-100: 333: 24.51
+	Hs
		156397 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RGRF2_HUMAN (255-580): 1.73e-98: 327: 21.15
+	Dm
		442976 RAP1_DROME (1-166): 4.93e-83: 244: 89.76		Q9VMF3_DROME (214-563): 2.5e-88: 300: 30.28
+	Hs
		897996 RAP2B_HUMAN (1-166): 9.28e-65: 198: 66.27		RPGF2_HUMAN (182-578): 7.88e-100: 333: 24.51
+	Hs
		486041 RAP2A_HUMAN (1-181): 3.65e-62: 192: 62.43		RPGF6_HUMAN (181-566): 5.18e-100: 334: 26.08
+	Hs
		925267 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Hs
		919625 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Hs
		925226 RAC1_HUMAN (1-184): 1.19e-73: 221: 29.08		SOS1_HUMAN (85-579): 1.45e-87: 297: 14.43
+	Hs
		919645 RAP1A_HUMAN (1-184): 5.85e-73: 219: 100.00		RGDSR_HUMAN (116-578): 3.04e-91: 290: 12.17
+	Hs
		897984 RAP2B_HUMAN (1-166): 9.28e-65: 198: 66.27		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Ce
		1089983 RAP1_CAEEL (1-184): 6.18e-73: 219: 80.95		Q19770_CAEEL (294-579): 2.05e-63: 221: 23.13